3D Bioprinting Biomimetic Blood Vessels

The lumen diameter of the 3D bioprinted blood vessel was approximately 500-600 µm and the thickness of the wall was ~400 µm. SMCs encapsulated in GelMA-Alg with alginate lyase grew fast in the vessel wall. This observation could likely be explained by the net generation of space yielded by the gradual degradation of alginate in the construct, which allowed SMCs to grow and proliferate more freely. Additionally, VECs also grew faster in the lumen of vessel with time and formed two distinct cell layers. The study was further expanded through the seeding of MSCs on the surface of the biomimetic blood vessel. It shows that our 3D bioprinting platform can be used to create small diameter blood vessels with biomimetic, three cell layer structures. We believe that the bioprinted vasculature produced in this study shows considerable promise for future application in both blood vessel repair and therapeutic discovery.

The poster is here: L0K21002-3D Bioprinting Biomimetic Blood Vessels.pdf